warning some of the rich mouth-watering meals you see on screen now are part of a controversial new diet though it's actually millions of years old it's sending shockwaves through the diet and weight loss industry because most people simply don't believe you could eat foods like this on any healthy plan or ever dream of losing weight yet the diet you're about to discover really isn't a diet at all it's actually return to what works naturally and that's why it works it's based on how we humans evolved for literally millions of years its wisdom lies in the fact that it ignores met contradictions discovered by doctors and nutritionists in the lab and takes us back to our room a time when nobody got that when we were all strong lean and had boundless energy and when there are no degenerative diseases with the true Paleo diet virtually every health benefit under the Sun can now be yours as I'm sure you've heard countless individuals around the world have turned to the Paleo diet and way of living in order to regain their health energy vitality and power just a few the benefits users report are leaner stronger muscles increased energy significantly more stamina clear smoother skin weight loss results better performance and recovery stronger immune system enhanced libido greater mental clarity no more hunger or cravings thicker fuller hair clear eyes and so much more in fact when you toss all the false nutritional info out their side and finally get back to your roots there's really no part of your health and body that doesn't get better in some way and that's why the Paleo diet is by far the fastest growing eating trend on planet Earth because the results speak for themselves there's only one little problem why most people fail to stay on the Paleo diet now given the amazing results in all the about eating this way you think it would be a breeze to stay on it right well for some it is but not all because unfortunately most of the advice out there like eat like a caveman or just meat and vegetables if you know real instructions for how to do this diet properly so what happens you get forward eating the same thing every day frustration kicks in and then you quit but it doesn't have to be that way paleo hacks already provides the very best community for supporting and encouraging each other with cutting edge information and truths about the Paleo diet and now for the first time ever the world's biggest most active community of paleo enthusiasts bring you all its most delicious most savory recipes sure cookbooks from a top chef are nice but what if you had one from a respected chef and hundreds of living active healthy paleo experts well that's exactly what you get with a cameo hacks cookbook it's a beautiful full-color cookbook you can use on your computer tablet or print and take with you anywhere it's the ultimate guide for making the Paleo diet amazingly good tasting fun and full a variety that not only makes you healthier but also satisfies your taste buds and cravings it's everything you could ever want it a guide for how to eat properly the paleo way without compromising taste or convenience as you might guess each and every recipe contains no brains potatoes lentils dairy processed sugars preservatives or packaged foods eat rich juicy mouth-watering meals that make your friends jealous just imagine while all your friends are counting calories suffering through yet another miserable diet or worse they're ignorant and eating random process fees that's aging them at warp speed you will be dining on some of the tastiest dishes you've ever had like these yes it's hard to believe these are actually on any diet but again hey Leo is not really a diet at all and if eating foods like this on a daily basis wasn't enough you'll be getting slimmer more energized of better muscle definition be sick less often your mood will be better your skin brighter and so much more still wondering if this is for you the Paleo hacks cookbook is for anyone serious about thriving on the Paleo diet for life yes the recipes in this book are universally healthy and as such can be consumed daily whether you're a stay-at-home mom or world-class athlete remember when you consume foods we as human to the vaults to eat while simultaneously eliminating over processed sugar land in peace now linked to causing many diseases we are now faced with in society your body will be provided with pure complete nutrition and all these key nutrients from protein to essential fats to fibers vitamins and minerals all of it assists in normalizing your body weight this is just one of the reasons why so many athletes are turning to the Paleo diet because the improves athletic performance and recovery yes we are designed to eat and live off the land to eat fresh fruits and vegetables nuts fees and animals this is the ultimate secret to optimal health losing weight Stanley improving performance reducing risk of injury and faster recovery and healing and when you get your copy of paleo hacks cookbook today you'll be eating healthy meals that do not result in you eating bland boring or tasteless foods you will be quickly cooking with fresh ingredients that provide the ultimate range of delicious flavors and we'll have anyone rushing to the kitchen to eat your next meal and that's true whether you're a pro or a total novice in the kitchen it doesn't matter the food prep secrets we teach you are fast and simple designed by many in the community who have been doing this diet for many years and know how to make amazingly good meals with taking forever or breaking the bank this is the single best way to eat rich foods and yet get so many benefits and therefore richer in terms of your health you will even learn how to cook desserts that are overloaded with sugar and white flour which often leaves you bloated heavy feeling or fatigued after eating and you will feel one hundred percent confident cooking delicious recipes without pasta rice bread and dairy you'll get 8 recipe categories that ensure you'll never have to eat a boring meal ever again the Paleo hacks recipe book covers all categories with well over a hundred step-by-step recipes and every single recipe within the following categories will excite your taste buds and have you cooking an easy three-course meal snacks meat chicken fish and seafood soups salads omelets and desserts you'll also get special recipe categories recipes for the 21st century hunter-gatherer chocolate capsicum sandwiches noodle recipes paleo eating for modern people paleo breakfast recipes focaccia as you can see we've gone through great lengths so you have every possible dish and every possible way to make this diet delicious with plenty of variety each day the paleo hats cookbook is so simple even a 6th grader could use it from the onset we make everything as easy as possible and assume no prior cooking experience or talent nothing is left to chance we walk you through each and every recipe point by point until your dish tastes amazing and looks fantastic on the plate we show you simple easy amazingly yummy Paleo recipes with a wide variety of easy to make paleo friendly meals that will get rave reviews from friends and family every time clear directions with exact measurements no matter what metric system you use you will easily be able to make these paleo recipes without any hassle absolutely everything you need to follow the healthiest diet in the world and to start achieving the health energy vitality and weight loss results you want to further speed your success and results with the Paleo hacks cookbook we're also giving you bonus gifts worth $135 absolutely free as a special one-time offer for anyone who buys on this page now we're also going to throw in free of charge five powerful female manuals that take your results to the next level these manuals help combat the two biggest reasons why people don't get the start they need to stay on the diet one they don't have the initial momentum needed to keep them on the fan until the amazing results become apparent and to social gatherings and eating at restaurants take them on a left turn away from the foods they should be and worse they can't get back into the healthy eating routine because it's too hard well not anymore with these guidelines you'll explode right out of the gate and become absolutely confident and savvy with all things needed to thrive on the Paleo diet including paleo guide quick start manual if you're having a rough time getting the results you want health and weight loss efforts because you're unable to make the long-term adjustments in your proof choices then this is the missing link you've been looking for not only with this manual educate you on the Paleo diet and give you the information you need to get started but I'm also going to ensure that you get results by showing you how to make an everlasting positive change towards your health this is an opportunity to stop struggling with reaching your health goals when you approach your health and your food choices in the right way your life will immediately become easier and more enjoyable with more energy more vibrancy and with less illness slowing you down so if you're tired of healthy eating being hard instead of easy make sure you don't miss out on this free bonus paleo eating out guide in order to solve the dilemma of eating out at restaurants and cafes we created a very helpful manual called paleo eating out guide it shows you how to stay paleo when eating out over a dozen example meals you can order for a paleo friendly breakfast lunch or dinner tips and secrets that ensure when you dine out you're not getting caught up by sneaky ingredients such as gluten and dairy by the end of this manual looking forward to going out instead of hiding indoors like many restrictive diets would leave you to do it and that's only the beginning you'll also get the paleo food guide just in case you're thinking the Paleo diet sounds fair and clean in regards to food choices we're throwing in another bonus because if you simply expand the category of vegetables alone you have hundreds of choices for flavor and texture combinations to choose from this paleo food guide will be your best resource for all food paleo that will help you start this diet with ease it will also help you score new territory within your own cooking and creation this guide covers comprehensive list of paleo foods list of in-season fruits vegetables and herbs paleo shopping list and so much more this guide alone is worth the price of the main cook book yet it's yours absolutely free when you download your copy of the Paleo hats cookbook today you also get our favorite the four ingredients paleo cookbook this is the coach book that makes cameo cooking easier than ever it's based on the wisdom of many of the most experienced paleo eaters in our communities it shows you 65cc to remember recipes that provide you as fast everyday paleo cooking options how to spend less time in the kitchen and less money on food by preparing delicious paleo recipes in the simplest way possible using for popular paleo ingredients and that means you no longer struggle for ideas to create a quick healthy meal last but not least you'll also get instant access to our 30-day paleo meal plan we save the best for last because in this final free guide you get 125 recipes from the paleo cookbook that has been expertly collated in the 30 day meal plan it's full of color photos of delicious paleo recipes the plan provides a kickstart for those new to the ato diet and offers new exciting ideas for existing paleo diet enthusiasts you'll know what to eat each day what to buy at the store how much to eat and went if you want to take it that far it's totally up to you our goal again was to make threatening on the Paleo diet both in terms of the health benefits and tastes absolutely as easy as possible and be done that exactly to sum it up you get the pan the daily Oh quick start manual to help you get started immediately the paleo eating out guide so you can still eat out and have fun the paleo food guide all the healthiest paleo food plus shopping lists the four ingredients helio cookbook healthy pros often eat each day and the 30-day paleo meal plan so you always know what to eat overall we could easily sell these items individually for $27 age or charge over one hundred fifty dollars for the entire package but you won't even pay 150 or 190 vynn 50 when you click the add to cart button below this video you get everything instantly for just thirty seven dollars that's easily eighty percent off the normal price plus you're protected by your generous guarantee become a paleo pro in the kitchen in just 60 days or your money back now we want to help your intelligence think that you'll love every recipe in the book or that'll make you look like a supermodel old bodybuilder overnight but what we will say is that in all the years we've built you work in this community we've helped thousands prepare food and drive with this diet and way of life and we believe you'll be no different so are guaranteed to you is this the pain you have scope cook must need preparing meals more easy more delicious give you more variety on the diet and help you experience the mental health benefits opinion much more quickly or your money back this isn't one of those no questions asked generic guarantees most companies offer you and hope you forget about because we stand by the results this program produces if you don't experience these results in the first 60 days simply email us and we'll immediately refund every penny you paid no questions asked if you already know paleo is for you are you willing to spend an hour and a few bucks so you can thrive on it when you download your package now you get the paleo hacks cookbook over 125 full-color mouth-watering recipes the paleo quick start manual to help you get started immediately the paleo eating out guide so you can still eat out and have fun the paleo food guide all the healthiest paleo foods and shopping lists the four ingredients paleo cookbook health approach often eat each day and a 30-day paleo meal plan so you'll always know what to eat worth a grand total of at least one hundred sixty two dollars yet you pay only thirty-seven dollars that's $125 off so what are you waiting for now that you know how easy and delicious paleo eating can be and now that you've seen what a difference it can make in your health and especially since you know how important it is to get healthy and fill your body with nutrition as more and more corporations strive to mess with our food from preservatives to GMO and worse let's move forward together armed with information in this video you can choose to spend a few minutes each day learning to prepare these amazingly satisfying Paleo recipes that you'll master and use for life to get healthier more energized slimmer and stronger or you can choose to go at it alone a serious mistake in our opinion especially since your purchase of a paleo hacks cookbook is fully guaranteed I think we'll have major consequences for your health and wellness in the days ahead but of course it's completely up to you for my part I sincerely hope you choose to join our community and using this priceless resource use it daily to get healthy and love what you eat and experience the best health of your life in 60 days or less starting today I know you'll make the best choice and I look forward to welcoming you aboard here's to cooking healthy paleo recipes .
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As I'm sure you've heard, countless individuals around the world have turned to the Paleo Diet and way of living in order to regain their health, energy, vitality and power. Just a few of the benefits user report are: Leaner, Stronger Muscles Increased Energy Significantly More Stamina Clearer, Smoother Skin Weight Loss Results Better Performance and Recovery Stronger Immune System Enhanced Libido Greater Mental Clarity No More Hunger/Cravings Thicker, Fuller Hair Clear Eyes And So Much More!
with just two days left until the new year it's almost time to start giving up the processed carbs and sugars and start eating keep you here with a diet that will help you drop the pounds fast is Esther Blum the author of the new book it's called k2 go get back that's right I love you alright so it's okay a lot of people try to cut meat out when they are trying to feel better but I think it's okay yes but the key is it has to be pasture me it has to be meat raised on grass because that contains omega-3 fatty acids okay oh no then how do you know you go to a butcher or your meat is specifically labeled pastured or grass-fed mean you never heard that pastured pasture and you can find it even at you know Trader Joe's Whole Foods I go to a local butcher so I'm very sorry that be like kosher almost it's definitely not kosher not sure animals are not raised pasture okay this is crazy the first dish that you have for us solid breakfast yes it's very good to me yeah gorgeous girls eat me this is the breakfast for you if you want to anti-age yourself raise your serotonin levels and dopamine levels in your brain fight cravings and give yourself a lean muscular body what does dunkin donut holes every morning that looks like heavy meat in the morning okay because and assuming this is pastured meats meat raises your serotonin and dopamine levels in your brain so it gets your brain awake and alert all day long I thought you weren't supposed to eat fruit then in the morning and you do have some some raspberries so what is that but that's what raspberries are chock full of antioxidants and they're a very low sugar fruit so I do encourage women especially to eat fruit because it satisfies that sweet carbohydrate cravings out you've got avocado and also that's breakfast tell us about the status ok the snack this is proud of friendly yummy beef jerky and again you can find beef jerky that is for animals in the effort and try some and I would encourage you to try any of these cuz they're delicious this is quite chewy ok you can make your own what's wrong nobody hurts you to pick a lot up this is a bread free sandwich because when you're on a patio diet the lettuce yeah you do them in and out burgers even do it I notice this is lettuce with a salmon cake instead of a crappy mega threes and omega-3 fats again excellent for brain health a woman fit for you good girl all right now we have job this is your this is a side salad this is your afternoon snack this is turkey and avocado dad I'll try oh good girls this is the time of day when women especially get those horrible cravings I'm fed twice now right that's right and I'm trying to teach you both fit you really need a ton of protein throughout the day I want you to know yogurt and granola all day and that is not another boost your brain biochemistry I love this that's great look I did I do this looks awesome now this is the lateral move people say especially women how am I going to give up carbohydrates at dinner and it's all about lateral moves so zucchini pasta is a wonderful lateral move and you don't even have to cook the zucchini we have that in our part what was that remember we have the what was it delicious yeah it's done and even children will eat this because you can say you know their dinosaur noodles and they're very low in carbohydrates super healthy for you okay is it also hot to know this is room temperature and if you use a hot sauce it will naturally cook the pasta anyway .
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Check out our cheap and easy-to-make paleo recipes ▶ ◀ ▶ ◀ Tags : going palate, have may But champ. soon many certainly is with flu.”) least into model like for a special including easy. of carbohydrates, there.
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Dhar Clarkson here with the daily BS got another question about gaining weight while sticking to the Paleo diet so sticking to paleo your carbs are automatically going to be pretty low compared to kind of a normal Western diet where people are eating a lot of processed grains so if you're on a lower carbohydrate paleo type diet basically you don't have to go out of your way to make sure that you're eating enough things like sweet potatoes or even regular white potatoes or some of the starts your types of vegetables squash potentially even things like carrots fall into that category but they're still not going to be quite as dense as I'm eating processed grains or if you're you know you're getting that post-workout shake where you're adding in something like pure glucose or pure sugar it's going to be easier to gain weight in that situation so what I suggest is either either not eating 100% paleo and adding in workout drinks where you're adding in sugar or some type of denser source of carbohydrates right after your workout and whether it's you know a little bit of extra rice or if you you know if you want to be extreme about it you're not really worried about gluten you could add something like bread or pasta how how sensitive you are to those those types of nutrients does I want to recommend most people most people that say just add in some extra potatoes extra rice and then if you if you want to add a workout drink I would add in pure glucose along with whatever whey protein or whatever protein source you're using for that particular workout drink but the point is is that you at some point need to add some denser source of carbohydrates which is gonna help spur some growth can give you an insulin response and is going to help you get bigger and stronger a little bit faster than if you don't get extra carbohydrates in your diet so I understand paleo is pretty tough I mean the the thing that I didn't mention that kind of goes without saying usually is that obviously you should be eating as absolutely much as possible of you know the healthy paleo food that you probably already eating so if you're not getting five or six meals a day you're not stuffing yourself full at all those meals then that's probably step one and then at that point if you're just still not getting enough calories and especially enough carbohydrates then you can start adding these things in on top of the Paleo food that you're already eating so give that a shot let us know if you have any more questions if you like this video or any of our videos make sure to share it on your Facebook wall by clicking share and then the Facebook icon and then also like it Thanks truck dogs .
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well I've been interested in this Paleo diet concept for a long long time I I first read boy Deaton's paper in the New England Journal of Medicine it was published in 85 and I read it in 87 and I thought it was just about the best idea I had ever heard on how can we optimize human nutrition and so that's really where my lifelong journey started was reading the cross references to that first paper and of course anybody who reads scientific literature you realizes that every article that you read has other cross references and so there was this incredible spiderweb of papers and so I ended up having tens of thousands of papers in those days we didn't have PDF files so my entire office was filled with all this you know I'd killed so many trees but that's kind of how the whole thing started and I have graduate students because I'm a professor to Division one Research Institute and we make our living by getting grants and writing scientific papers so this was kind of my hobby that ended up becoming my not just avocation it became my passion and that's how the whole thing happened and early on in the game I took a couple of my PhD students and I said hey if we're gonna eliminate two food groups and processed foods what in the hell are we got left what is it the diet going to look like are we going to end up being deficient and that's kind of how the my books came about is I found out not only are we not deficient is that we are absolutely sufficient we are incredibly rich diets by eliminating these foods so this is kind of what this talk is all about and that's how it evolved and you've seen this slide before is that these foods comprise 70% of the energy in the u.s. diet but they were rarely or never consumed by our hunter-gatherer ancestors and so it was never my intent and the the press the popular press got this wrong and because I was at Ground Zero and this concept people that read about it they don't they don't go back and read our original papers what we were trying to do we were never trying to replicate a hunter-gatherer diet precisely all we were trying to do was to emulate with foods that you could basically go down and get the supermarket or Whole Foods or you know your your grass produced meat folk or so that's what we were trying to do and you can see here that these are the foods that I'm suggesting was there anything in Stone Age times that look like that no carrots were not big and orange there were tiny little things the size of your finger they were white or purple and you didn't get much out of them and same way there was no such thing that looked like this the meat looked a little bit like this and the wild fish looked a lot like that there was nothing here but when you eat these foods it does a tremendous amount of good for our bodies and so there's no real absolute Paleo diet this is a rule of thumb so you practitioners just take this with a I don't want to say grain of salt but realize it is a little bit of wiggle room here so this is usually what we see in hunter-gatherers on average is a little bit more than half their energy from animal foods and the balance from plant foods they didn't eat grains and they didn't really process their foods and so the typical macronutrient breakdown then is very high protein tends to be lower in carb and fat tends to be sometimes lower but mainly it was higher and so we really can't eat wild plant foods like this Coon woman showing us her guru of berries in Tama melons and we can't eat unprocessed fruits and we'll talk about the difference between the two is that the wild plant foods are typically smaller more fiber less sugar so the amount of fructose that you get in an apple or in grapes you don't really see that very often and people with the metabolic syndrome should stay they should watch their intake of this until they get their body weight reduced in their insulin sensitivity normalized now there's slightly greater minerals because we don't harvest the wild plants you're in and you're out and then take the entire plan away from the field so the nutrients the minerals go back into the soil for the next generation of plants whereas in a modern field we take the plants away and we gradually deplete the minerals vitamins are determined genetically so they're about the same there's some variation here if you look species to species these are the 20 most commonly consumed vegetables in the u.s. diet so any vegetable is fair game particularly ethnic markets and whatever the only ones that aren't potatoes maintain glycemic responses that are very non paleo light and they also are very high sources of anti nutrients they contain a variety of alkaloids and lectins that Pedro Bustos may talk to you about sweet corn is a grain so it's eliminated and beans green beans are also eliminated because in their native state most legumes are in digestibility nutrient content those are the 20 most commonly consumed fruits as I mentioned you need a little bit careful with some of these fruits if you go to my website I actually have a listing of the fructose content of all commonly consumed fruits so you can advise your patients which are the low sugar fruits dry fruits you need to be careful with because they can elicit high glycemic responses athletes and people that have exquisite insulin sensitivity it doesn't seem to be much of a problem particularly in training these are the 20 most commonly consumed seafood we are depleting the world's ocean of wild fish so there are sustainability issues here that really transcend the the Paleo diet one of the things that I would be careful with our farm fish because it reduces the long-chain omega-3s and increases omega-6 is frequently there Fred fed cereal grains so we can't most of us don't have the luxury of eating wild game meat and many of us if you've ever tried it you say it tastes gamy you don't like it but we can get grasped reduced domestic meats and that's a good second choice so if if you look at wild meat as I mentioned earlier wild game is very very lean and in Colorado we have a lot of game and so we've done human interventions with wild game and doing nothing else and it seems to improve blood lipid profiles so you can get domestically produced grass and past your meats that are fairly similar to wild meats and you can see one of the reasons why they're much more expensive but by the whole carcass and so my wife and I that we live in Colorado and that's how we do it would buy half a side of grass produce bison or a half a side of beef get it processed cut up and we've got a couple of freezers that we put it in now that two of the boys are out of the house and in college not so much anymore but we were eating a ton of meat at the time um so what are other strategies to enrich the omega-3 fatty acid content of a contemporary Paleo diet let me just go back here is that the amounts of omega threes milligrams per 100 grams of beef is relatively low so you you won't if you were to eat only grass produce beef you can see here here's the total omega-3 even though you get almost 100 milligrams 100 milligrams isn't going to cut it and so let me show you what you really need to do and you need to take a couple of dietary strategies when you're on a contemporary or modern Paleo diet again grasp reduced meats they taste better healthier typically less exogenously alit into them hormones and and pesticides and whatever fatty fish salmon is a really good way to go eat a couple times a week or mackerel and you're in good shape supplement with fish oil I don't recommend cod liver oil because cod liver oil is a mixture of vitamin D and a and it turns out that that mixture may not be so good so if you're going to get fish oil get it from the flesh of fish omega-3 enriched eggs or better yet get free-ranging eggs they taste better so if we look at the recommended omega-3 fatty acid intake these are the long-chain epa and DHA you can see we have four categories here we have the current north american intake which is significantly which is way too low and you can see what the American Heart Association recommends for the coronary patients and so the the difference the gap can be as much as 770 milligrams per day yet you can see here that by simply consuming a quarter pound of Atlantic salmon you can get as much as you need for the cardiovascular protective effects and it tastes good so these are the ten most commonly consumed nuts and seeds in the US diet you can see those and this next table shows you the fatty acid composition and you can see that most nuts are very high in linoleic acid and six fatty acids and they have virtually no long chain fatty acids and very few of them have alpha linolenic acid or eighteen 3n3 which is an omega-3 but that has to be chain elongated in the liver to the longer fatty acids to really have biological effects so the point here is is that you can derail contemporary Paleo diet by eating a ton of nuts and dried fruit and whatever and thinking you're having a healthy diet but actually you're having a high glycemic load high linoleic acid diet so this is not a good strategy use them in salads use a handful occasionally but don't eat it the hell out of them every single day so here's some healthful oils and their characteristics or what are thought to be healthful hunter-gatherers never ate any oils so there could always be an argument saying that you shouldn't do it but as far as I know there are no really adverse health effects of any of these well flaxseed there's some papers some epidemiologic papers suggesting there's a link with prostate cancer but the experimental studies in animals don't show it so all the rest of these seem to be fairly helpful including coconut and as I mentioned coconut oil ends up being helpful because even though it may elevate blood cholesterol it doesn't seem to increase the risk for heart disease and it seems to lower inflammation because it contains high amounts of lauric acid or 12 : zero okay so when I decided that let's let's check this out let's see what happens if we try to eat a contemporary diet based on the food groups that our hunter-gatherer ancestors ate but foods that we could get at the supermarket and so I had a graduate student Lynn tewi she ended up getting her PhD and has become fairly well known in in the health industry she ran about three or four hundred of these computerised dietary analyses for me I said let's do everything we can possibly do so we got a stack of papers and it takes you a little while to key it all in and then to analyze and whatever so this is a representative daily meal plan for somebody eating paleo and you can see so she starts off and this 25 year old female who's eating 2200 kilocalories starts off eating cantaloupe broiled salmon for breakfast lunch great big salad pork chops dinner is another huge salad steamed broccoli and lean beef and for dessert just a big bowl of strawberries and she can snack pretty much all day long with these carrot celery sticks and oranges so we made up all kinds of plans so this is was fairly representative of what we saw and we wanted to contrast that to the USDA recommended diet and so the USDA changed from being a food pyramid to being my plate in 2011 and so that's what we're going to do is I'm going to show you what the nutrient characteristics of a contemporary Paleo diet looked like and we're going to contrast those to the food pyramid or the food plate so the food plate replaced the pyramid in 2011 and really there was not a whole lot of difference other than taking if you look here the little diagram taking the kind of they still recommend exercise but they've just taken the stair steps out of it because they thought this was too confusing and this was easier for the average person to get that's why it was done but the no real substantive changes so what are the goals of the pyramid the plate they want a diet that's adequate and protein vitamins minerals there's no DRI for fiber they suggest that they should eat twenty to thirty five grams a day and obviously all these other things calories fat this is this is a horrible recommendation right here because it's not based on good science so it's not a quantitative issue it's a qualitative issue yeah let's get the trans fats out of the diet let's get some of the the unhealthy fats out of the diet some of the isomers that are made with food production saturated fat doesn't seem to be an issue anymore the meta-analyses out of the Harvard School of Public Health in the last four or five years tell us that saturated fat really it wasn't the boogieman we once thought it was I'll show you a cholesterol has virtually no effect on the diet this one is kind of misleading so for those of you that are out there with your pen and pencil on that slide multiply sodium by 2.5 4 and that tells you how many grams of salt are in the diet so this looks kind of like a low number but when you multiply it by two point five four you can still see the recommend recommended values for salt are way too high so if we compare the USDA recommendations to what we actually consume in the u.s. diet you'll notice then that we ate too much sugar we don't get enough fiber compared to what the pyramid recommends we're pretty close to the fat recommendations but we're fatter than we've ever been so it doesn't seem that fat per se has a much of an effect on obesity and it may not have much in effect on cardiovascular disease or cancer either and maybe dietary factors that promote inflammation are more important okay and so you can see we've been good little boys and girls and we've gotten our cholesterol values down below recommended but I'll show you here it doesn't matter it really doesn't matter and we still eating way too much salt so if we look at the these were our das our DA's were changed dris in the last ten years or so and the Centers for Disease Control in the USDA hasn't published the data in this fashion but to me it was just wonderful so the numbers are still about the same this is data that goes back to nineteen ninety four ninety six and you can see then that the thirteen nutrients most lacking the US diet almost everybody doesn't get enough zinc almost everybody doesn't get enough calcium but I'll show you in a minute that may not be problematic if you're doing other things and about half of the population doesn't get enough b6 or vitamin A so those are the thirteen nutrients most lacking in the u.s. diet so if we summarize the differences in actual versus recommended values well this is nothing new too much sugar not enough fiber too much fat too much saturated fat too much sodium the total fat saturated fat we're going to examine and as a population we are deficient in these trace nutrients most often now what I wanted to do is I wanted to contrast the Paleo diet you that contemporary one where we started off with the cantaloupe and the salmon for breakfast I wanted to contrast that diet to the food pyramid the food plate and see how it came out so a couple of things stick out almost immediately are getting way more protein than what we get in the food pyramid food plate the question comes up is that therapeutic or does it have adverse health effects we get considerably lower carbohydrate and is that therapeutic or does that have adverse effects and how do endurance athletes cope with this we have a little bit fewer sugars because we're still eating a lot of fresh fruits and vegetables but there are no processed sugars and high fructose corn syrup certainly isn't in any of it or getting considerably more fat as you can see we are one of the the ones that really stands out is the food pyramid food plate sitting still makes no recommendations for long-chain omega-3s in the diet which to my way of thinking is totally foolish whereas in the contemporary Paleo diet we're getting a ton of it and if you look at the sodium to potassium ratio you can see how far out of whack the plate pyramid is compared to what we have you know this is an interesting one that just totally blew me away the very first time that Lynn - II started making these printouts we started looking at them consistently again and again and again we saw these numbers and if you look at the food pyramid or food in play and you look at the percentage of the trace nutrients for all these dris the Paleo diet just absolutely blows it away look at those numbers it's so much more nutrient dense so the question that came up in my mind was why is this if we we've eliminated two food groups and processed foods why is the nutrient density so much greater well let's take a look so this was the next thing I did and we published this in a JCM paper and I don't know how much standard dieticians took note of it but they should have so we got the various food groups that you could eat with a contemporary Paleo diet whole grains you wouldn't drink whole milk but we threw them in there anyway fruits veggies seafood meats nuts and seeds so then what I did is I ranked each one of these food groups with a superscript from 7 to having the highest concentration to one having the lowest and then what I did is I sum the ranked scores and put them down here and so what these values then represent is the nutrient density of a specific food group and so this this approach had never been taken and to me if we're going to make recommendations to what people should should and should not eat it's kind of like if you're a coach on a track team and you don't know how fast your runners can run should this guy be a a sprinter or an endurance guy so we need to know what the overall nutrient density of a food group is before we make blanket recommendations right so why are we telling the entire population to eat grains and drink whole milk when at the end of the day these are nutrients that come up at the bottom of the stack humans don't have a grain requirement there is nothing no nutrient that we can't get without eating grains the same way with dairy products we can get everything we need without dairy products now a dairy industry will tell us we can't get enough calcium so we're going to examine that a little bit more detail so if you decide to eat and gary products and whole grains you're gonna displace other more nutrient-dense healthy foods and that's why these numbers came out so great for those trace nutrients so these are the to summarize these are the important differences protein is higher carbs lower cholesterol is higher calcium is lower and vitamin D there's none we have zero vitamin D in any of those diets that I've shown you so those are the issues that we're going to look at is there too little calcium in contemporary paleo diets we don't have any vitamin D is there too much cholesterol and how about all that protein is that good or is that bad for us so those are the issues that came out of these computerised dietary analyses let's first off take a look calcium intake and see how we can get around that we look at the actual u.s.
diet we don't make the DRI ourselves so this is for that 25 year-old woman we only get about 70% of our calcium Paleo diet is similar gets 69% but with no dairy products and the food pyramid ends up getting 122 percent because it includes dairy products regularly so anytime you look at a trace nutrient in the diet what you really need to look at is balance and it's it's misleading to look at one side of the equation only and so the dairy industry would tell us that if we're looking at calcium all we should look at is how much calcium is coming in not how much calcium we lose in our body and so these are the sources of calcium in our diet it's the amount ingested but as I'll show you here in a minute that the calcium curves show that most of the calcium that we ingest is not absorbed so if you drink a glass of milk about 75 percent of the calcium is not absorbed there are tricks you can do in a truce nutritionally to increase the absorption rate and then there are things we can do to reduce the calcium the urinary calcium loss rate and that seems to be the strategy mother nature through evolution has taken so that all mammals can build strong bones and maintain healthy bones throughout their life if they live in their normal ecologic niche so elephants and rhinoceroses and deer and elk they all tend not to get osteoporosis in their normal native niche whereas captive animals sometimes do so let's consider calcium input the input side of the equation DRI is a thousand milligrams and so if a woman consumes 2200 kilocalories the calcium density required to achieve the DRI you simply divide the DRI by the kilocalories and that gives you this critical number 0.45 5 milligrams per kcal food is what's required well let's just go through and analyze this and once again this approach had rarely been taken so if we analyze food groups you can see here's our here's what we need to make the DRI there's the magic number there's only two foods that can do it one is whole milk and the other is vegetables well hunter-gatherers didn't drink milk so this was out all right this is what they had to do this is what they had to play with to get this number assuming that that number is correct so let's look at the caveat so this is the key evolutionary template we had to place over the model and come up with a solution and that's really what this evolutionary template helps with is to come up with these solution to complex diet health related problems so if we look at the mean calcium density and there's 20 commonly consumed vegetables we eliminate potatoes and corn and green beans then the frig calcium content of those 20 vegetables in the u.s. diet is 1.28 milligrams per kcal now you know this you can kind of fiddle with this number a little bit depending on which vegetables you're looking at so if you put in more leafy greens there issue with leafy greens oxalates and so forth but let's just take a broad average number and that's what we come up with so that's a thousand milligrams of calcium divided by one point two eight we have to eat 35 percent of our energy from vegetables all right well is that reasonable it's it's tough to do but it can be done so particularly you know if you steam your veggies and and so forth and you make an effort to eat a lot of vegetables at every meal you can certainly easily get the DRI without doing calcium so how did these guys these guys certainly didn't drink milk and how did they survive and have healthy bones there are some DEXA studies of non westernized populations in which we examine the bone mineral density and it doesn't seem to be a huge problem so people living in in tropical African environments not drinking milk seem to still have healthy bones okay so let's look at the output side of the equation so remember calcium balance is more important than either the input or the output side and a net a diet that produces a net acidosis then tends to increase calcium losses and you'll hear more about this later this afternoon a typical Western diet as I mentioned yields a chronic metabolic acidosis this is one of my colleague Tony Sebastian's co-workers it publishes way back in the 80s and that example diet that I gave you the one that started off with the cantaloupe and the lettuce and all those salads and whatever we calculated the values using Remer and manse's a way of doing it and for Linda in the crowd the reason I did it this way was because it was simple than your equation so it took me a little bit longer but I suspect it would come out fairly close using both techniques and so what are some of the values that can help with calcium input side of the equation increasing absorption and so sunshine increases vitamin D absorption hunter-gatherers were pretty much outside all day long they got a lot of vitamin D that helps and recently it's found out that dietary protein also increases intestinal calcium absorption so the earlier studies showing that high dietary protein caused calcio rhesus well yeah it increased the calcium losses in the urine but if you don't measure the difference between what is absorbed then you don't really know if you're in calcium balance or not and those beth dawson hughes finally got around to doing those studies about five or six years ago and we now found out that high protein yeah it increases calcium losses but it also increases calcium absorption and it tends to promote bone growth because it also stimulates igf-1 so the bottom line then it's possible to achieve dris on non dairy foods calcium balance is a bigger issue and just to keep it safe try to get thirty to forty percent of your calories from fruits and veggies just like the model we showed and one of these days we'll have an dietary intervention in which we actually evaluate that so no natural foods are very few natural foods I'll put it that way have concentrated sources of vitamin D and get a little bit in cod liver oil and marine mammals and started in the 50s and the 60s milk and margarine were fortified with vitamin D so that's where most Americans get it from two food groups that I don't advocate you consume in contemporary paleo diets because of the trans fat issue and margarine some margins that we can make now without trans fats but I still think they're they have isomeric fatty acids besides trans fats that people don't tell you about so there's isomers that are produced in these processes which are probably just as lethal as our trans fats so hunter-gatherers then had to get all of their son or their vitamin D from solar synthesis the exception is this polar hunter-gatherers could get a significant amounts of vitamin D from marine animals what are the recommended values I'm preaching to the choir here so I don't have to spend a lot of time with this slide is that we're trying to achieve plasma concentration somewhere between 40 and 70 nanograms per milliliter as practitioners I know many of you monitor this closely and you try to get your values up to that and this is Michael holux work and others that have been in Hollis's have been studying this for their entire career so the recommendations the DRI is 600 I use just don't cut it you've got to to get people that are deficient you've got a supplement to the tune of anywhere from two to seven thousand IU's and then once you achieve that magical plateau of 40 nanograms you need to take one two thousand I use per day or get yourself out in the sunshine like this guy did and I did when I was a young man lifeguard for 20 years in a beach in California okay so how about cholesterol intake if you look at the cholesterol in the u.s. diet we've actually done what the government told us to do we got our intake below 300 milligrams and the food pyramid or the Paleo diet is way high and the food pyramid is low so is that going to cause a problem this dietary cholesterol have an adverse effect on health there's an equation called the Howell equation and there's an earlier one that was published in the 60s but this is the most recent version and what it does is it allows us to predict how dietary saturated fat polyunsaturated fats and cholesterol impact plasma cholesterol in the vernacular if we have any statistics out here this is referred to as a multiple regression equation and it predicts one variable from two or more variables so if we take that Pawel equation and we lower the amount of cholesterol from four 90 one which is what we had in the example Paleo diet down to 300 it only drops plasma or blood cholesterol by four point five milligrams per deciliter any of you that our practitioners realized that we don't have that kind of precision or resolution can you you can't measure cholesterol one day and then measure it the very next day in two different labs or three different labs and get the same results so there's very few labs that can measure it to this kind of precision and you can see then if we cut it from 491 to 219 if you start off with high blood cholesterol it only reduces it to point 5 percent which is as I mentioned beyond the scope and resolution of most studies the pds ratio seems to be very important this is an older study showing that if you get a dietary p2s ratio that is greater than 80 you can add all the dietary cholesterol you want to your diet and it has virtually no effect on plasma LDL and we talked about cardiovascular disease I don't know if James O'Keefe has arrived yet but he'll probably talk to you a little bit about that it's not so much the plasma LDL it's the oxidized LDL and the ratio of these particles to one another and so hopefully James will be able to give you the lowdown so the bottom line is is that dietary cholesterol seems to have very little or no effect on blood cholesterol levels and actually saturated fat may have an important effect on the HDL to total cholesterol ratio okay the final point I want to talk about here is dietary protein so people that have been vegan or vegetarians we've been under this myth that high-protein diets have adverse effects on kidney function and this came about by a fella by the name of Brenner in New England Journal of Medicine many many moons ago suggesting that high protein increases glomerular filtration rate GFR s and it causes glomerular sclerosis and when that happens then we have blood albumin falling out of the circulation into urine and that suggests that we've got kidney malfunction so people that have pre-existing kidney disease you put them on lower protein diet GFR goes down albumin gets out of their bloodstream and bingo so it must be protein that's causing the problem well that's really faulty thinking and I don't know how it ever made it got published in New England Journal because it wouldn't in this day and age so we know that higher proteins elevate GFR that's nobody's doubting that all right and vegetarians have lower GFR s but the question that really needs to be asked and answered is do high-protein diets promote kidney disease and it wasn't until 1999 that our nias drops group University of Copenhagen did this experiment they put people on a high-protein diet and they ran it for six months and they didn't see any albumin appearing in the urine and the GFR actually increased but the kidney volume increased as well so the kidney or the GFR relative to kidney volume remain the same so the conclusion was is that in healthy normals high proteins had very little effect on kidney that was the first study done there was a really eloquent one that was just completed in 2012 showing the exact same effect so I remember speaking in Germany back in the late 90s and the German press was all there and I was telling them that you ought to eat high protein to help your blood lipid levels and they're all looking at me like I'm nuts wait a minute how does that work and Bernards Wolf's group in Canada was the very first folks to show this that when you replace carbohydrate with protein it had a very therapeutic effect and here's his results this this study has been if it's been replicated once it's been replicated 50 times since then so we we know this again and again and again Nurses Health Study this is Frank whose work from the Harvard School of Public Health showing that higher protein diets reduce the risk part disease in the Nurses Health Study and high protein diets then elevate metabolism because of their thermic effect if you look at protein it's two to three times the thermic effective either protein or fat or carbohydrate this in the long haul probably doesn't make a whole lot of difference because to lose a pound of fat you have to reduce your caloric intake by 3500 kilocalories so this is maybe affects people overall the long haul years and years and years but probably the major effect of how protein helps people to lose weight is it's much more satiating than his carbohydrate or fat and so there's at least thirty or forty studies have been out in the last forty years showing this more recently shown by badder hams group and the mechanism now is fairly well understood pyy is certainly involved it's a a hormone secreted in the gut which influences the hypothalamus to help reduce hunger and a high protein low glycemic load carbohydrate diets now our could have been conclusively shown to be about the best way in which we can lose weight once again going back and looking at the historical literature our nias drops group showed that a high protein group lost more weight than another this result has been replicated and here's the really cool study right here is this one by Weigel at all and this one was a randomized controlled trial in which they eliminated the criticism of the earlier studies so if you're interested find this one and then the other study is the Diogenes study the Diogenes study is ongoing study in Europe and it is shown with a enormous sample size five or six hundred people that not only is a high-protein low glycemic load diet the best way to lose weight it's the best way to keep weight off so contrasting that five other diets so Diogenes di oggi en es so MEDLINE that one and you can get that data ok and high protein reduces the risk for stroke and I'm going to finish up here so that our next presenter will have a little bit of time to come up and get ready to go so high protein seems to reduce the risk for stroke and epidemiologic studies there's five different types of epidemiologic studies for every one you find that one effect you can find two others that don't have the effect so what we really need to look at our interventions in which actually control these variables and here's a cool intervention showing that lean beef lowered blood pressure if you have a higher protein diet it seems to improve survival time for patients with breast cancer this is the Harvard group as well and so going back to the recommendations I think we need to consider is this type of a diet thank you very much .
Video Description:
There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust. In conjunction with this discordance between our ancient, genetically determined biology and the nutritional, cultural, and activity patterns of contemporary Western populations, many of the so-called diseases of civilization have emerged. In particular, food staples and food-processing procedures introduced during the Neolithic and Industrial Periods have fundamentally altered 7 crucial nutritional characteristics of ancestral hominin diets: 1) glycemic load, 2) fatty acid composition, 3) macronutrient composition, 4) micronutrient density, 5) acid-base balance, 6) sodium-potassium ratio, and 7) fiber content. The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization.
morning so it's a real pleasure to be able to speak to this group I've had a lot of admiration for dr. Vazquez and his staff for putting together a world conference like this it's a real pleasure for me just to be able to walk into it and do my thing so Alex thank you so much okay let's go ahead and get started the talk I'm going to be giving is based on a paper our research group published in 2005 and to say the least I've got a little bit of mileage out of this paper I've been all over the world and it's a topic that I think many people are very much interested in so any time we're talking about the origins and evolution of the Western diet what we're really talking about are the origins of humanity itself and what I'd like to do is walk you through this slide and talk about some of the key points here so the first notion that I want to bring up is the idea of what is a hominin a hominin is a bipedal ape or an ape that walks upright and if we look at the archaeologic record the bones themselves what we find is there's perhaps 22 or even more species of hominids that have existed since the divergence of hominins with apes and so if you look down here the way this chart is set up is that this is the time frame in millions of years and the earliest hominins and these may have been pong kids or Apes appear in the fossil record between five and six million years ago and some mitochondrial DNA evidence as well as nuclear DNA evidence supports the archaeologic evidence that that was a split between pong kids Apes that walked on all fours versus ourselves that walk on on too and so as you move through this there's a couple of key points here this is a period called the Pliocene and the Pliocene started about five million years ago ended about 1.7 million years ago and this is really when a lot of the action occur when we have all the speciation and so each one of these rectangular boxes represents a species of hominins and as we move from the green the lower right-hand corner up to the very top here's our own species Homo sapiens which appear in the archaeologic record about 200 thousand years ago and that's corroborated by the mitochondrial DNA evidence as well as the nuclear DNA evidence we are the only living hominids and the action really got going and this is what we'll be talking about in the next hour so the action really got going from the Pleistocene onward and that's when the very first members of our genus Homo appeared so let's take a look and see what we owe one other final point there was no universal quote/unquote Paleo diet okay so there was all kinds of variations of this dependent upon the species their ecological niche the season of the year geographic location everything and so I think that kind of enters into the equation with modern-day paleo diets is there's really no single version of this alright so what did we know about that plyo Pleistocene period what were they eating we know that all species of hominids were eating both plants and animals so they had an omnivorous diet and this is kind of a cool slide in that the photographs that were taken here were taken in the late 60s and early 70s by an anthropologist by the name of richard lee in botswana and so here we have a woman and you can see these are the fruits of her gathering and if you look carefully you'll see what looks like kind of a modern-day watermelon except it's about the size of her fist that's called a tama melon and over here are some roots and if you look carefully this is the digging stick that she used to dig those roots up here's some groovy berries and right here in the middle for those folks up front you can see this is a tortoise so she got both plant and animal foods when she was out hunter gatherer and of course the men are sitting in the background doing absolutely nothing while she brings home the the food um this photograph is kind of interesting because what Richard Lee wanted to do he wanted to see if these Kuhn people could actually butcher an antelope with a stone tool so if you look carefully a hand axe that was built these things were made starting about 1.5 million years ago they wanted to see if they could actually book butcher it and indeed they could so what are some other evidence to show that all of the hominid species that we looked at on that second slide that they were omnivorous we could look at the diet of our closest living ancestors Jim pansy and this is a photograph Richard Wrangham at Harvard gave me and you can see here that there's two male chimps and they're actually they've killed antelope and they are dis articulating it with their hands so it's real difficult because they don't have large carne seal teeth to tear it up like a big cat so they have to do it with their hands and it takes them quite a while to ultimately eat everything and they they do go into the the skull and they put their fingers through the foramen magnum and pull out brains and eat those which I will show you here maybe later in this lecture how eating brains might be have been a good thing so about 65 grams of meat a day during the dry season so what are some other evidence to show that all of these hominids were omnivorous this is a stable isotope data from Julia Lee Thorpe and mats pon himer he's at CU she's at the University of South Africa and what this is it's a measurement of an isotope called Delta 13 carbon and you can see right here we have more c3 these are c3 plants and what what c3 plants are they're their herbs and shrubs and leaves and berries and so forth whereas c4 plants are basically grasses and sedges and so if you look at the isotopic signature of a grazer or an animal that eats grass you can see it has more c3 so it has less negative Delta 13 carbon signature and so this is what we see if we look at a browser an antelope or an animal that consumes leaves and berries and fruits and whatever it leaves this signature now what I want you to look at is look at the signature of an obligate carnivore here's a leopard right here and here's an extinct saber-tooth cat and so notice that they have a mixed signal and the reason that they well they don't eat any plant foods at all the reason that they have that mixed signal is because they're eating the flesh of animals that are either grazers or browsers and so if we look at the early hominins if you look at Homo in pre anthropos and Australopithecus which are these blue ones you can see that they also have a mixed signal as well so no living ape eats grasses and they're into Jesta becuase they contain high amounts of cellulose and we don't have the enzyme no mammal has the enzyme cellulase to break down cellulose so the way that you can break cellulose down is by evolving a large hindgut where you can ferment the cellulose we don't do that know primates do that except for well there's one there's a baboon over here that does it and you can see this is this baboon right here they're open thickest so it's the only one that does it and it ferments that the grasses and the hindgut so I just published a paper and maybe some of you have seen it the prettiest seedings of the National Academy in which we actually rebutted the popular press suggesting that grain eating had been done millions of years ago it wasn't and this is the evidence for it so the uncertain this is what comes up during that plyo Pleistocene period is how much plant food and how much animal food or all those 20 species consuming well I really don't have a good data set to say one way or the other one thing that we can say is started in about two and a half million years ago maybe even earlier maybe even three and a half million years ago they were consuming more and more animal foods in their diet so let's see what that evidence is starting at about 2.5 million years ago we see the very first lithic technology and this is called the old doll and tool tradition and it appears in East Africa Ethiopia about 2.5 2.6 million years ago and ther e are two parts to these tools if you look carefully this fellow up here that's actually dr. saman and he was the discoverer of these tools and he's the guy that dated them there's two parts to them there's a core and those sharp flakes and so you can see those sharp flakes and modern-day experiments have shown that these are very these flakes are very effective at dis articulating and butchering large animals and the core can be used to crack open the skull and get it brains and as I mentioned brains are a very good source of arachidonic acid and DHA and so nervous tissue and brain requires a source of AAA or DHA to be healthy and to actually synthesize nervous tissue and then you can see here the the core can also be put on a hammerstone and crack open marrow marrow doesn't have very many long-chain fatty acids but it's got a ton of triglyceride in the form of monounsaturated fats kind of like nuts or olive oil so in the archaeologic record this is what we call a smoking gun and this paper was published in science in 1999 and if you look carefully let's take a look over here on the left-hand side of the slide and you can see there's a scratch mark on the medial surface of the jaw and if we magnify that and then actually look at they scratch through scanning electron microscopy what appears is not just a random scratch but deliberate cut and we know this wasn't made by 9 of carnivores or random rocks rolling around with a fossil in a creek bed because it leaves a very distinctive cut and so what they were interested in doing if this is the medial surface of the jaw what what organ you think they were going after tongue yeah exactly they were going after the tongue and so our group actually have gone in and looked at the fatty acid composition of the tongue in wild animals and it turns out the tongue is also high in monounsaturated fats like marrow and for modern humans monounsaturated fat from animals tastes good so Plains Indians like to make their pemmican out of marrow rather than storage fat because it has more monounsaturated fats and it tastes better to us and over here you can see that these percussion marks showing that they extracted marrow from these long bones okay there's a also additional evidence to suggest that during that plyo Pleistocene period our ancient ancestors were consuming more and more animal food and this is called the expensive tissue hypothesis put forth first by Leslie Aiello in 1995 and if we look at the brain size of modern humans we have these huge brains yet we have a gut that is much smaller than what would be expected for an equivalent 60 kilo primate and so that's really the the essence of this idea is that brain is the most metabolically active tissue in our entire bodies and it takes up about nine times more watts of energy as we're just sitting here than any other organ combined so 9 times more energy is devoted to driving the brain yeah and so if our bodies were all brain our entire bodies were brain think about what our metabolic rate would be would be absolutely enormous so as we evolved a large brain then the expectation would be that the overall metabolic rate would be greater than what would be expected for a primate but it turns out that wasn't true is the overall metabolic rate was exactly as predicted and so then what happened as we evolved a large brain our guts trench and so what is the interpretation of that is that when we're eating a diet more like our chimp ancestors primarily a fruit it took a very large metabolically active gut to digest all of that fiber and once we started shifting over to eating more and more calorically dense fats and brains and meat then it allowed for the selection of a smaller gut because there isn't absolutely no negative selective pressures with doing that there's other evidence as well to show that we are consuming more and more meat in our diet and one of that is the very first members of our genus Homo appear in Africa roughly 2 million years ago and they made it all the way up to 40 degrees north latitude by at least 1.8 million years ago and I come from Colorado and we're at about 40 degrees north latitude we're also a little bit higher elevation but starting in around November the ground is frozen and there's virtually no plant foods that are available and hunter gathers don't store things so what that means is they had to develop the behavior to eat and kill and scavenge animal food at the lower latitudes so that's also suggestive that making it up to this high latitude even during the interglacial periods when europe and asia or warm they still had cold seasons so it is also indicative they are eating more and more animal foods this is an idea that our group had came up with in 2002 and we contrasted the metabolism of cats which are obligate carnivores to humans and cats have made a number of evolutionary adaptations to their all-meat diet and first off cats can't synthesize touring it's conditionally essential amino acid that all cells have to have for optimal function and so cats simply can't do it they've lost there's a an enzyme that the liver makes that allows it to take precursor amino acids and turn them into taurine and so cats have got a a defect in the gene that builds that enzyme and they can't do it but there's absolutely no consequences so they still have very high taurine levels taurine is only found in animal foods it's not found in plant foods so where did they get it they got it preformed you eat animal foods you lose the ability to make taurine humans if we feed infants formula which we did back in the 70s and 80s that is devoid of taurine their plasma concentrations of taurine decrease if you decide to become a vegan vegetarian your plasma concentrations of taurine as well as urinary concentrations will decrease because it is suggestive that that enzyme that we have also not like cats we haven't completely lost the ability but we don't do very well and similarly we can look at all these other enzymes and and pathways and what they tell us is that cats because they're getting these items these nutritional items preformed it doesn't matter whether they lose the ability to synthesize or not synthesize so here's that here's a good one right here is beta carotene beta we can make beta carotene and liver are we fightin a from beta carotene in the diet but cats can't do that at all they they simply become very deficient and ultimately die so that process in humans is inefficient so what can we say we're not obligate carnivores but we've moved down that metabolic pathway towards eating more and more animal foods so the question comes up then is how much plant food and how much animal food were actually consumed in these these ancient diets and so there really is no answer it's kind of like well you know is there a single Paleo diet no there was a variety of plant animal food subsistence ratios and that's what our group actually went in and analyzed we analyzed what's called the ethnographic data and ethnographic data is historical data that has been published by people that went out in the field looked at hunter-gatherers frontier doctors and they made notes about these folks so it's pretty loose data it's not randomized controlled trial it's not empirical it's more subjective but anyway it's the only day that we have so we went in and reanalyzed the 229 hunter-gatherer societies that were reported in the ethnographic atlas and here's what our data showed is that if we looked at the subsistence dependence on gathered plant foods there were as I mentioned 229 hunter-gatherer societies and these little blocks here called class intervals so 0 to 5 percent plant food all the way up to 86 to 100 % plant foods and the statistical analysis what we did is we looked at the mode which is the most frequently occurring value 26 to 35 percent plant food and the median the value at which the numbers 1/2 fall above and half fall below is the medium and that spout w as found in the same class interval 26 to 35 percent so basically that's indicative of what the average hunter-gatherer was doing in terms of plant foods about quarter to a third of their calories came from from plant foods and if you notice up here there was not a single vegetarian or vegan Society of all 229 and only thirteen and a half percent of these hunter-gatherer societies had greater than 50% of their calories from plant foods so at least the ethnographic data is supportive of the notion that we were eating more animal foods and that's included both hunted and fished and gathered as well animal foods and so you can see here that the representative value the mode and the median falls in this 55 to 65 percent so a little more than half the calories to two-thirds seemed to typically come but once again as I mentioned this is really kind of soft data ethnographic data is not empirically based and so there's lots of room for error here and we we did actually compile the hunter/gatherer data in which we have quantitative studies and I can tell you the photographs that I've looked at from this time period look at how rip these guys are look at those six pack AB so that's pretty characteristic of our ancestors that weren't eating processed foods so this is a paper we published in 2002 and European journal clinical nutrition in it we actually compiled the 13 quantitative studies in which people had gone into the field they measured the amount of food the weight then they went back they got the caloric values for those wild plant foods and then they made a fairly good estimate and notice here that the numbers we see are about 70% animal 30% plant but when we eliminate the very far north societies the Eskimos and the Inuit that live above or the noonah mute that live above 60 degrees north latitude well they have no choice but to eat only animal food most of the year when we eliminate those we see a number then it approaches the ethnographic numbers of about a third to plant food to two-thirds animal food this is my colleague Mike Richards work he was at Oxford when he did this study and he examined another isotope that is found in the collagen of these fossils if the collagen is intact and he compared Neanderthal Delta 15 nitrogen in two speed or two examples of Neanderthal two specimens and he contrasted them to fossils that are found alongside the Neanderthal so we know they're from the same time frame a wolf and arctic fox and then here's some herbivores that they find and you can see that the signature of the Neanderthals indicates that they were eating a ton of protein from animal food well Neanderthals aren't us that's a different species and so they were living in Europe during very cold periods so let's take a look at the data let's go fast forward in time to England and this data comes from about ten or twelve thousand years ago you can see it was dated in a place called Gus cave in England twelve thousand three hundred years ago and once again the same Delta 15 nitrogen of these and these are modern-day humor they were exactly like us no difference exactly like us and you can see that they against again we're having a signature that was even greater than an arctic fox but nothing like a deer a horse or an ORAC or ox so the animals we domesticated to become cows alright so this is the known if we look at the plyo Pleistocene period that we talked about these are the foods that simply couldn't have been consumed because they didn't have the technology to make these highly processed foods that are essentially formed 70% of the calories in our diet so one thing that's kind of interesting and I give interviews and to the media and the press all the time is that the average person on the street is unaware that we eat the same four things every day day in and day out okay and so 70% of our calories comes from refined vegetable oils cereal grains refined sugars and dairy products if you eliminate those then what's left and I'll show you here in a minute so every single day of life of the average American they eat those those foods in processed forms in one way or another so this is another way of looking at this and so I've deliberately made this pie chart in which those four food groups dairy grains refined oils and refined sugars are in white because they're very nutrient they're poor a nutrient density and so what they do is they displace the more colorful foods and you can see here that meats and fish and nuts and fruits and veggies then are a very nutrient dense and what I'm suggesting people ought to do is with modern foods is to or with a modern diet eliminate these foods so that you allow all these nutrient-dense foods to fill in here's another way of looking at the the Western diet we can talk about as it evolved and the Neolithic was the first major change once we no longer were hunter-gatherers but were farmers this was the Neolithic period from 10,000 to about 5500 years ago this is when things really started to change we started to domesticate animals we started to domesticate cereal grains we settled down in villages and even though 10,000 years ago seems to be historically remote if you look on it from an evolutionary timescale notice that 10,000 years is really very very small in terms of human generations only 333 human generations have come and gone since agriculture began in the Middle East and for most of us it's even shorter still most people of Northern European ancestry agriculture didn't come into play until about five or six thousand years ago okay if we move even faster forward we can look at the industrial era which started about 200 years ago and this is when things really got geared up in terms of processing foods sucrose really wasn't available to the average citizen until about 200 years ago with the advent of the steam engine and being able to get sugarcane from the tropics back up to northern latitudes and do it inexpensively so this is when people could start eating refined sugar in high quantities feedlot produced beef were only made possible with the advent of steam locomotives in which you could get cows to market along with huge amounts of grain and put them into a feedlot so this is you can see less than five human generations since we started making beef that looks like it does now refined grains are very recent in our diet because the machinery to make refined grain steel roller mills didn't exist until the 1880s vegetable oils hydrogen or hydrogenated oils and most people in this crowd are old enough to remember a time or many people are when we didn't put high fructose corn syrup into our diet this is kind of a fun one and I I've got a little mini paper and it shows pretty much the advent of junk food so believe it or not there actually was a time when we didn't have Hershey's chocolate bars at the supermarket and here's there's a couple ones here that are kind of fun here's M&Ms 1941 I remember coaching a being an assistant coach on a women's swim team we would go on break you'd have to go to the bathroom go into a service station and they'd empty out the candy machine you know girls at that age they're swimmers they were just absolutely craving these refined sugars so look at that 1913 an Oreo cookie I can't believe they'd invented those they'll never they'll never go away though you know okay so when you look at this thing in an it's in entirety and you look at the neolithic and the industrial era of foods and what they do they displace all those other healthy foods but in a couple of papers that we've examined the nutrient content you can see what's going on here it disrupts these nutritional factors these major nutritional factors the glycemic load the fatty acid balance the macronutrient balance and I'll talk about how all of these things changed trace nutrients vitamins minerals phytochemicals acid base sodium potassium and fiber and to this list as Alex had mentioned you can probably talk about anti nutrients because the typical Western diet contains high levels of anti nutrients and in the swansong of my career that's what I've been focusing on is how anti-nutrients disrupt the gut biome and predisposes for autoimmune disease but that's another lecture okay so let's take a look at cereal grains you know cereal grains of the staff of life and hunter-gatherers didn't eat cereal grains and so they comprise roughly a quarter of the calories in the typical Western or US diet unfortunately we eat our cereal grains as refined grains rather than whole grains am I saying whole grains better idea not necessarily there's trade-offs with both of them so what are grains the seeds of grasses and in their wild state they're typically very small difficult to harvest and they're really into jess tubulin less you grind them down and then cook them so that's what you have to do to make them edible and with hunter-gatherers they didn't like to do that there's a concept called optimal foraging theory in which they're trying to get the most bang for the buck so the amount of energy that they expend has to be equivalent to what they get back and if you've got to put all this processing energy into eating it then they become starvation foods so the appearance of these these are called saddle stones these crude grind stones in the middle-east roughly ten to fifteen thousand years ago heralds the beginning of humanity use of cereal grains is staple and once again we published a little rebuttal in the Proceedings of the National Academy and then we published a more extensive paper my colleagues Pedro and Milan who will be speaking to you later on we wrote a little bit larger article on this notion and rebutting the idea that people were eating grass seeds and grains way way back so up until about 1880 this is how cereals were milled you can see here's a woman still started two thousand twenty five hundred years ago we invented water wheels so that we could turn these great big heavy stones with the force of a machine and the inherent difference with the new technique is that these things grind the the entire seed together so the endosperm the germ the brand they all are in the flour and unless you go through another step to remove them then that's how bread and flour were made until for the average person until the 1880s in the 1880s steel roller mills came into play and they fundamentally break the wheat very differently they squeezed the wheat berry so they squeezed the germ out of it and then it's very easy to sieve off the germ and the fiber and have nothing left but the endosperm and when you do that what it does is it creates a flour that is very very fine and has a high glycemic index and so in this chart right here you can see you can start off with a whole wheat kernel and it has very low glycemic index and the more and more fiber and bran we take out the higher the glycemic load becomes so we produce this nice beautiful white uniform flour but physiologically we do all kinds of damage to our bodies and in 1880 and 1900 the glycemic index was still a hundred years in the future so we didn't understand what it was we were doing and as you can see here virtually all processed foods that are made with grains whether it's wheat or corn or rice or you name it they typically have high glycemic indices and high glycemic loads this is my colleague Jenny Brand Miller's work and she published this stuff and she continues to do so and so she arbitrarily drew a line in the sand and said that medium likes emic index foods are between 55 and 70 I don't agree with that so I've been down to Australia a few times and I think more importantly it's the glycemic load so it's the glycemic index times the amount of carbohydrate not in a standard portion but in an equivalent portion so I think you have to look at an equivalent portion to make the plain feels level so this is David Ludwig's work and semen lose and and this is some of the earlier stuff that really kind of told the public a few vitamins we call it enriching it and so after World War two these B vitamins b12 and three were enriched as well as iron I'll show you that on the next slide and then starting in in nineteen ninety eight we put folic acid into all refined grains but paradoxically folic acid didn't exist until 1948 nobody on the planet ever ate folic acid until 1948 when chemists at leaderly labs synthesized the compound folic acid and Foley are not the same compound so when we refined grains you can see then that we're knocking the hell out of folate and this is what's left and then we replace it with folic acid and the reason that that was done is that it was thought well folic acid the liver turns folic acid into folate and it was thought that this would reduce the number of neural tube defects actually mortality from neural tube defects and we published a paper showing that yeah it did but was it significant we put 300 million people at risk by supplementing our diet with folic acid to save roughly a hundred and fifty lives okay so that's why it was done and there was only one other country that followed lockstep with the United States and that was Canada so none of the European countries decided to do that because there was experimental work at the time suggesting that this isn't a very good thing to do and what we've seen in the decade or decade and a half since the folic acid supplementation program is an increase in multiple epithelial cell cancers and so there's some really good randomized controlled trials in which they give people men in particular folic acid because folic acid also is supposed to reduce cardiovascular disease and turns out is what happens is that prostate cancer morbidity and mortality rose dramatically and in animal models we now have a mechanism of how this might work so this to my way of thinking is going to turn into enormous public health blunder that hopefully will be reversed in the not-too near future so mineral depletion occurs also with when we refined our grains and you can see here that virtually all minerals are are reduced when you consume a whole grain from a refined grain but this is misleading because in vivo in the body it doesn't work this way so what happens is most of these divalent ions iron and zinc and manganese and all of these are bound to phytate in a dose-dependent manner meaning that we don't absorb them anyway so when we eat whole grains we get probably even less iron then what we would get with fortified iron so it's a mission there's a trade-off here and the other trade-off is that whole grains are a much more concentrated source of anti nutrients which Pedro Bastas will be talking to you about later in the morning so there's a variety of diseases then that are associated with the reduced fiber content and one of the common questions that come up when people adopt Paleo day that they say how am I ever going to get my fiber if I reduce all these whole grains well you can see then on a per caloric basis here whole grains are a pretty source pretty poor source of fiber and the types of fiber that tends to have therapeutic effects in our body soluble fiber versus non soluble fiber except for oats grains don't have a whole lot of this or as you can see here fruits and vegetables are wonderful sources of fiber and if you take these things out of your diet you get plenty of fiber so how do we know that dairy products couldn't have been consumed so end of story right somebody in the popular press calls me I said have you ever been close to a wild animal no have you ever tried to milk a wild animal okay so you have to domesticate animals before you can milk them so that didn't happen until about 10,000 years ago you can see this is the content of dairy products in the typical Western and US diet about ten percent of total energy and this is data in which they actually look at the fatty acid composition on pottery shards and they can see that indeed that fatty acid composition comes from milk and dairy products and so first dairy in evidence comes from the Middle East about 9,000 years ago we see it in Great Britain about 6,000 years ago all right one of the ideas that got me interested early on and once again the idea came for it as Alex kind of mentioned from this paleo template and it led me to not just rheumatoid arthritis but it led me to many other health problems so I take this evolutionary template and I place it over that whole idea and so we were some of the first people to blow the horn on diet and acne in the flagship the American Medical Association is flagship journal the archives of dermatology and that was 10 or 15 years ago so what led me to that was the same thing that led me to the rheumatoid arthritis that has now led me to autoimmune disease was this evolutionary template and you can see here is that if we look at the glycemic index of milk products they're very very low okay they're very very low so in theory they ought to be pretty good for insulin and glucose metabolism yet if we look at the insulin response it's like eating cookies or white bread or sugar so paradoxically the glycemic response and the insulin response have been disassociated and we were the second group internationally to point this out to my graduate student Garrett Hoyt and indeed we saw this effect and it was shown earlier by Jenny Brando group and a few other folks so the question comes up then is that a detrimental effect so some people have suggested that a low glycemic load and a high insulin response might be therapeutic animal models of that show that's not the case so if you ever go to an Italian restaurant and you order up veal okay what is veal it's calves very small cows that have been intensely fed milk over the first couple of months of their life and then they're slaughtered and so this is well known in the animal science community that doing that feeding high milk diets way beyond what they could ever get from suckling from their mother essentially forced feeding a milk causes insulin resistance hyperglycemia and these other problems so there's only been one study in the clinical literature with humans this is Kristin Hoppy's group and she reported in a jcn in 2005 that if you gave these young boys their protein as either milk or meat during the arm of the study in which they were fed milk they all became insulin resistant so we need to replicate this study in adults and have colleagues that are on the process hopefully of doing this shortly okay so we ate wild animal foods which are it's really not practical to do that anymore but what are what are the changes that occur in the nutrient content of animal foods as we go down the line here from wild to grass produce to grain produced so our ancestors ate everything they the entire carcass whereas what we eat is simply the muscle meat when we talk about me that's what we eat and most typically it's grain produced or processed and so here you can see if we look at the fat content by energy not by weight of America's favorite meats you can see there the not meat at all their fat disguised as meat so very high fat concentration in these and it doesn't look anything like wild animals and we've done those experiments we've actually done that and in wild animals the body fat content waxes in ways seasonally yet once we domesticated animals we could provision them with food and we weren't stupid we slaughtered them and that when they are at peak fat content because we could do that we're at the mercy with wild animals whatever fat they have is the fat they have and so this represents the change in body fat in caribou over the course of a 12-month period and this is fairly reminiscent of not just North American but also European and African mammals that humans would have preyed on so you can see that the body fat over the course of seven months is quite low it's about three or four percent anybody that knows about body fat realizes that in humans this is a very very low value and in North America only during the fall and that's what we have hunting seasons in the fall does the body fat increase so we did these experiments a decade ago and we analyzed the total fat the fatty acid content in wild animals grass produced animals and grain produced animals and you can see here that the amount of fat in this feedlot cattle is an order of magnitude higher and you don't have to be a scientist to do the analysis look at the differences in the carcass there's no subcutaneous fat here whereas these guys have three or four and five inches and the triglyceride infiltrates the the muscles here and you don't have that with wild animals so it wasn't until about 150 years ago that we started to do this started to feed aunt cows grains and it fundamentally altered a couple of factors it changed the fatty acid balance it reduced the omega-3 content it reduced the macronutrient balance and now we're producing a meat that contains a lot less protein and because there are less vitamins and minerals in fat than there are in protein we reduced the nutrient content as well with that process this just contrasts the the omega-3 and omega-6 fatty acids between grass and grain produced animals and the big problem here is the high levels of linoleic acids so you can see we have maybe 50 or 60% more linoleic acid and that that does represent a problem I will try to finish up here on time at 9 o'clock we'll take a short little break and then I'll come back and do my second one so potentially we can at least add to the amount of omega-3s in our diet by eating grass fed the amount of mega threes that we need or roughly 10 times higher than what you would get from a quarter gram serving here so these are part of the solution and not part of the problem but they don't cure the problem and I'll talk to you how we'll do that later okay added salt is rarely consumed we eat about 10 grams of salt primarily you can see from processed food a little bit from cooking and very little in naturally occurring foods this is a mountain of salt found in catalona Spain and when I went over and spoke to my friends Milan and Pedro and showed this slide about half the audience put their hand up said I know where that place is they've actually seen that mountain so salt was rarely used by hunter-gatherers perhaps those living close to the ocean may have dipped their food in salt water but inland hunter-gatherers there's really no precedents for it and here's the laundry list of diseases that are associated with the high salt content here's one as practitioners you may not know this comes from an obscure paper in the journal of the American Medical Association 1944 and if you have patients that aren't sleeping well get the salt out of their diet another one this comes from our group is exercise induced asthma we blew the whistle on that a number of years ago and let's talk about refined sugars depending on whose numbers you're looking at anywhere from 15 to 20 percent of total calories this is USDA disposal data this is where it comes from it's changed a little bit over the course of the year hunter-gatherers are hard-wired for sweets and fatty foods the brains seek it out because it has survival value but they couldn't eat it in unlimited quantities so honey would have always been consume but it was only available seasonally this is good per capita disposal data out of Europe showing that prior to the Agricultural Revolution hardly anybody in Europe ate sugar so Denis were out of business this is data from England and you can see then that except for the two world wars sugar consumption rose steadily into about 1970 this is data from the United States over the last hundred years or so and we've actually made a little bit of inroads into refined sugar consumption it peaked in 2000 and over the last decade it started to decline a little bit there was a fundamental change made in the types of sugars that we were consuming prior to the advent of high fructose corn syrup being m ade with this technology that you see up here most of the sugar came from sucrose so is there any difference between sucrose and fructose in terms of how it influences our body a little bit ok so one is a compound and and and one or two elements so we have an enzyme in our gut to break sucrose into glucose and fructose so it may be a little bit less problematic but probably not much so you can see then that hi this is our data high fructose corn syrup is increased dramatically over the course of the last 30 or 40 years and this parallels nicely the obesity epidemic in the United States and so many people think that fructose is underlies part of the problem I don't think it's the only problem but I think it certainly it's part of it so you can see then that it all peaked in about 2000 as I mentioned fructose and sucrose have similar effects in the body but not identical so here's some of the diseases that are associated obviously dental caries any society that consumes high amounts of sugar typically ends up with dental caries there are individuals that seem to be resistant but as a population most don't do so well the metabolic syndrome now is very well characterized and also epithelial cell cancers through mechanisms that we outlined in 2004 that are now fairly well recognized is that breast colon and prostate cancer all tend to be promoted via the hormonal cascade that insulin resistance produces okay vegetable oils they comprise about 18% of total calories and we use these in all kinds of processed foods and you can see how they're broken down prior to the Industrial Revolution the only way to make these things was by rendering and pressing and so the first oils that were made were traditional olive oils and flax oils and what have you most the oils were used for lubrication and not as food oils and so starting in in the last century or so you can see this machine up here this is a steel expeller and it creates an enormous amount of pressure and it can extract oils out of seeds that you like corn corn doesn't seem like it's an oily food but it can extract oil out of them and then by using purification procedures and in solvents and so forth you can get all of these non-traditional oils and put them into your diet the hydrogenation process was invented in 1897 so that we could harden them turn them into margarine and another shortening and other fats and this is a first time we end up with a specific type of fat trans Ladak acid in our diet and trans elated gas it seems to cause multiple adverse effects this is the per capita consumption of refined vegetable oils the United States and you can see starting in about 1900 we did practically very little at all and we almost increased that by 500% since the year 2000 tell you one little anecdotal story here and then we'll call it quits take a little break and come back and do the next lecture but my grandfather moved out to California Southern in the 1920s and he started a restaurant and in Hollywood and so his restaurant served probably about two or three hundred people maybe and after he died he died in the 40s my mother inherited all his stuff and one of the things she got was a cookbook that he had purchased back in 1913 that's what it was dated and it was a cookbook and a recipe on how to cook for 300 people and so I ultimately got that after my mother passed away and I went through that recipe book and the only oil in the entire recipe book was olive oil and there was very few recipes that used it they used lard and other fats but they certainly didn't use any anything near to what we use now so in that timeframe just in the three generations that I've lived this has gone from practically nothing in our diet to 20% of our calories so what are the problems with consuming high amounts of processed foods and refined vegetable oils it alters the fatty acid balance in our diet and most of these vegetable oils are very high in an 18 carbon fatty acid called linoleic acid and it used to be thought that linoleic acid was a good thing and there's still it's somewhat controversial in the scientific literature but not to my way of thinking and so this actually it was thought to lower blood cholesterol and reduce the risk for heart disease but reanalysis of some of the classic studies by joe hibblen and and other folks in our group showed exactly the opposite and so linoleic acid tends to be pro-inflammatory so this is a bad thing so if you've got and guess what inflammation drives all chronic disease you can't have heart disease you can't have cancer and you can't have autoimmunity without up regulation of the pro-inflammatory response so this is involved in that problem and that's why you can see it is associated with all those diseases so in all of their brilliance the USDA came up with a new thing they went from the food pyramid to my plate but for me it was even easier to zap this one all I had to do is put an X over here and an X here and now we're kind of back to paleo so there's some fundamental differences we have with that but this is what I think people ought to try to do is you should emulate not exactly or precisely the diets of hunter-gatherers we can't do that and I'll show you in the next lecture how it's impossible but what we should try to do is to emulate the food groups that they consumed and eliminate the food groups that they didn't consume so this is what I think we ought to do thank you then the next lecture is a little bit shorter so want we take a five to seven minute break try to be back here between five after and ten after and we'll get going on the next lecture and hopefully have a little bit of time for Q&A at the end of all these lectures .
Video Description:
There is growing awareness that the profound changes in the environment (eg, in diet and other lifestyle conditions) that began with the introduction of agriculture and animal husbandry ≈10000 y ago occurred too recently on an evolutionary time scale for the human genome to adjust. In conjunction with this discordance between our ancient, genetically determined biology and the nutritional, cultural, and activity patterns of contemporary Western populations, many of the so-called diseases of civilization have emerged. In particular, food staples and food-processing procedures introduced during the Neolithic and Industrial Periods have fundamentally altered 7 crucial nutritional characteristics of ancestral hominin diets: 1) glycemic load, 2) fatty acid composition, 3) macronutrient composition, 4) micronutrient density, 5) acid-base balance, 6) sodium-potassium ratio, and 7) fiber content. The evolutionary collision of our ancient genome with the nutritional qualities of recently introduced foods may underlie many of the chronic diseases of Western civilization.
