if you are a physician or you are a person that studies multiple sclerosis and you're up on it you know that one of the other destructive agents in multiple sclerosis is a substance called matrix metalloproteinases MMPs just another laundry list of things that go bad with multiple sclerosis the MMPs disrupt the blood-brain barrier it allows the t-cells to cross the blood-brain barrier and do their damage in the CNS it also is specifically involved in the degradation of a myelin basic protein lo and behold guess what here's WGA look what WGA from wheat germ does it up regulates these matrix metalloproteinases and the same thing PHA also does this now these are all tissue cultures we haven't shown this this is what's called in vitro the in vivo studies are yet to be done and hopefully with groups like direct MS these kind of funded studies will be done okay we're coming to the very end here and I'll try to finish it up maybe just a minute or two after milk and dairy products have been repeatedly associated in the epidemiologic literature with multiple sclerosis so milk drinking a time and again is associated with this autoimmune disease as well as others rheumatoid arthritis and type 1 diabetes this is just some recent research and I'm not going to bore you with all the detail how this is a busy slide I realized that we made it that this was a bad one except for the nice-looking little mouse in the milk on the corner probably didn't get much across on it but let me just say that the key thing here is that there is a a protein in milk called beauty row filament all right and we know that beauty row filling in a rat model this little brown rat down here in the corner we can cause a disease that looks a lot like multiple sclerosis in this rat model by giving it this specific protein beauty row filling that occurs in milk but the crucial part is here is that it's only when we immunize these guys remember the polio virus with the adjuvant if we just give it the straight detail filling and we reintroduce it in the nose or IV it prevents the disease we have to have the adjuvant with the protein to cause the problem and here's another little mouse that the same thing occurs and whoops and this is a little mouse called the SLG sjl mouse and we find then that we can induce a AE in this mouse model and that there is structural homology with another milk protein called bovine serum albumin now how all these proteins cross the gut milk milk proteins are like any other proteins that can't get across the gut they're degraded by the gut protease --is so how does beautyrx o'phelan or bovine serum albumin get past the gut our old friend WGA binds casein and casein is the fraction in which these proteins occur so if this whole they're latching a hold W J is latching ahold of casein and dragging it through this Trojan horse the epidermal growth factor receptor and this is just a summary that yes indeed these these milk proteins are associated with that and one caveat here in this slide is that the neonatal exposure to these dietary antigens predisposes people to susceptibility later in life we know that if you feed children milk at age one it increases their susceptibility to type one diabetes okay if you feed them grains early on it increases their susceptibility to a variety of autoimmune diseases now the proof is in the pudding and I mentioned I'm going to finish up here I'm only a few minutes late according to my watch the proof is in the pudding what we need are randomized controlled trials in real people with multiple sclerosis this unfortunately is anecdotal evidence that Ashton is providing me and this is an N of four we only have four people anecdotally is not well control it's not scientific like what we want it to be and so you can see here we've got four feet we've got one woman a subject number one in red and she has had multiple sclerosis you can see for 22 years before she adopted a diet it was grain legume and dairy free and at the time we didn't know about tomato electon now we do we should have taken tomatoes out of her diet as well and you can see for the first time in 20 years this is an index of the disability scale that people experience with multiple sclerosis called the the Kirksey extended scale and you can see here for the first time in her life she didn't get worse all right so she's remained the same and then you can see that here we have a person that went into complete remission and this person you can see only had Ms for about what three years maybe and then here's another one that had a significant improvement in symptoms so we think that the key here is is that if you catch the disease early particularly if it's remitting relapsing ms you can probably stop it in its tracks with diet okay if you're 20 years down the road we can't really I don't think we can we can change things but we can make it so things don't get worse so with that thank you why don't why don't you pick out the question here so I could show a bias to the crowd okay why don't you stand up and then I will repeat your question if I can hear it from here well if we look at the question is is what you say 15 months if if we have a 15 month old baby and they're drinking milk what should we be seeing them well if we look at the example the evolutionary example from hunter-gatherers is they didn't wean their children until about three or four years of age believe it or not so that's the normal setting and once they weaned them they never had milk in their entire life so the notion that we need to have milk is what I believe not a necessary factor and if you if you go to my website WWll you can download my scientific papers and you can read why you don't need to have milk in your diet so I we don't feed I've got three boys 16 14 and 9 we don't feed our children milk and we have it so well the question the question was is what you do so they don't get osteoporosis later all right well how did humanity for two million years deal with the notion of not drinking milk ten thousand years ago nobody drank milk and we know from radiologic studies of hunter-gatherers that they had very powerful stress or fracture resistant bones how does that work we have been in the Western world we've been brainwashed so to speak in that bone health has everything to do with the input side of the equation in other words it's calcium coming in but that's not how it works bones health is determined by the balance between calcium coming in and calcium going out okay it's like a checking account so you can have a million dollars come in in your account in other words you can drink all of milk you want but if you're losing a million and a half dollars bone health is going to be compromised and what we believe is that acid-base balance and diet is way more important because acid-base balance and diet determines the loss of calcium in the urine and so if you're in a slight affluence load to your kidneys all foods upon digestion yield either an acid or alkaline load to the kidneys if you if you have an alkaline load to the kidneys then it promotes bone growth also paradoxically what we found is that high meat diets prevent osteoporosis because they up regulate a hormone called igf-1 so let us just say that evolution has figured this out okay evolution has figured out how to build strong bones here in alberta you've got mountain lions that are running around with incredibly powerful bones every wild animal out here is running around with incredibly powerful bones evolution worked this out .
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